Who we are

The development of a single drug takes on average 10 years and costs 1.3B$ today. On top of that, most of diseases remain untreatable. We imagine a world where the most severe diseases can be treated and cured. Our goal is to design effective therapeutic proteins in days at a tiny fraction of today’s drug discovery cost.

Cinference uses deep learning to design new protein therapies instead of discovering them in a costly and lengthy experimental process. Our multi-disciplinary approach to protein design allows us to explore the uncharted territory of the protein sequence space, enabling us to design proteins with superior therapeutic effects.

Our timing is perfect! 2021 has been a breakthrough year for biology. Google AlphaFold solved the 50-year-old grand challenge of protein structure prediction. This breakthrough marks the beginning of a new age in protein therapeutics and a first glimpse into the potential of machine learning to understand hidden principles of protein design. There couldn’t be a better time to join us on the journey to free millions of people from their diseases.

We are funded by some of the best investors in the world and are about to disrupt the classical drug development model.

Learn more about our core values here and watch a short intro video here

Your role

As one of the first members of the Biology team, you will directly work with the head of biology and establish the PoC. You will be involved in the laboratory setup at the Life Science Factory. You will be one of the key colleagues at our Göttingen site. You will work on life-changing therapies with leading researchers from Europe and directly report to our cross-functional teams of machine learning scientists, biochemists, structural & computational biologists, and software engineers.

Your responsibilities

We are looking for an enthusiastic colleague to join our biology team in Göttingen. Key tasks include:

• Designing a high throughput cloning strategies
• Expression and purification of recombinant proteins in E. coli and mammalian cells
• Establishing and developing in vitro mammalian cell-based assays
• Biophysical characterisation and protein quality control using thermal unfolding analysis (nanoDSF)
• Building and screening of protein libraries using display technologies (Phage display)
• Preparation of internal reports, presentations, and protocols

About you

We know – sometimes, you can’t tick every box. We would still love to hear from you if you think you’re a good fit!

• Ph.D. in related fields of Biochemistry or Synthetic Biology
• Strong scientific background in molecular biology and protein biochemistry
• Experience in molecular cloning, recombinant protein production, and mammalian cell culture
• Hand-on experience with BLI (Octet) and characterizing biophysical properties of proteins
• Experience with ELISA and display techniques for protein-protein interaction
• Experience with data visualization and analysis
• Experience with membrane protein production is a plus
• Cell-based assay development and FACS-based sorting are a plus
• Knowledge of protein engineering and structural biology is a plus
• Ability to operate independently and to design and perform complex experiments in a fast-paced environment
• Strong organizational, excellent communication, and interpersonal skills.
• Driven, self-motivated personality who is open to learning and establishing new methods
• Fluent in English

What we offer

• Impact. The opportunity to truly make a difference in the world by building a next-generation biotech company that designs affordable protein therapies for the most devastating diseases
• Be part of a caring, ambitious, honest, and diverse team. People at Cinference have worked at organizations such as McKinsey, IBM Lab, Max Planck Institute, and Memorial Sloan Kettering Cancer Center before
• Learn. Gain experience in laboratory management, protein, and experiment design, and learn from our experienced cross-functional team. We operate in one of the best-equipped labs in Europe.
• Appreciation. Attractive salary, all the equipment you need, and 28 days of vacation
• Well being. Join our regular team dinners/events in Berlin and Göttingen to connect with your team

Application

To apply and learn more about this position, contact Christian and Nikolay via wetlab@cinference.bio with your CV and Cover Letter. In the email subject, please add “(Junior) Scientist – Protein Biochemistry“

The Cover Letter should include the following: Your technical expertise and how you have applied them in previous projects, your motivation for joining Cinference, and the earliest starting date.

We are looking forward to your application! 😊

Summary

• Position: Working student position with 15-20hr/week
• Location: Göttingen

Who we are

The development of a single drug takes on average 10 years and costs 1.3B$ today. On top of that, most diseases remain untreatable. We imagine a world where the most severe diseases can be treated and cured. Our goal is to design effective therapeutic proteins in days at a tiny fraction of today’s drug discovery cost.

Cinference uses deep learning to design new protein therapies instead of discovering them in a costly and lengthy experimental process. Our multi-disciplinary approach to protein design allows us to explore the uncharted territory of the protein sequence space, enabling us to design proteins with superior therapeutic effects.

Our timing is perfect! 2021 has been a breakthrough year for biology. Google AlphaFold solved the 50-year-old grand challenge of protein structure prediction. This breakthrough marks the beginning of a new age in protein therapeutics and a first glimpse into the potential of machine learning to understand hidden principles of protein design. There couldn’t be a better time to join us on the journey to free millions of people from their diseases.

We are funded by some of the best investors in the world and are about to disrupt the classical drug development model.

Learn more about our core values here and watch a short intro video here

Your role

As a working student, you will be directly working with the scientists in our wet lab. Your main responsibility will be protein work and in addition, helping with laboratory management.

Your responsibilities

We are looking for an enthusiastic working student to join our biology team in Göttingen. Key tasks include:

• General lab work: Preparation of buffers, reagents, and media.
• Molecular biology: Performing ****PCR and recombinant DNA cloning.
• Bacterial work: Preparation of competent cells, transformation, and expression of therapeutic proteins.
• Protein characterization: Purify target proteins, perform biophysical assays.
• Laboratory management: Maintain ELN, inventory, and device maintenance.
• Collaboration: Analyze data and prepare presentations for the engineering team.

About you

We know – sometimes, you can’t tick every box. We would still love to hear from you if you think you’re a good fit!

• Currently enrolled as a student at a university doing a major in biochemistry or related fields.
• Strong scientific background in molecular biology and protein biochemistry.
• Experience in DNA cloning and bacterial protein expression.
• Hands-on experience in protein purification and quality control.
• Ability to work in a fast-paced environment and interest in startups.
• Strong drive, sense of ownership.
• Good communication skills in English.

What we offer

• Be part of a caring, ambitious, honest, and diverse team. People at Cinference have worked at organizations such as McKinsey, IBM Lab, Max Planck Institute, Memorial Sloan Kettering Cancer Center before.
• Impact. Shape a young company and its culture from the beginning to achieve its mission – creating a world in which the most severe diseases can be cured.
• Learn directly from our Scientists designing and optimizing high throughput therapeutic protein screening methods in a multidisciplinary deep-tech start-up and get insights into protein design, the biotech, and pharma industry.
• Appreciation. Competitive working student salary of 12€/hr. Regular events with the Göttingen team. Furthermore, the Life Science Factory is a highly innovative place with many startups and startup-related events.

Application

To apply and learn more about this position contact Christian and Nikolay via wetlab@cinference.bio with your CV and Cover Letter. In the email subject, please add “Working Student Protein Biology”.

The Cover Letter should include the following: Your technical expertise and how you have applied them in previous projects, your motivation for joining Cinference, and the earliest starting date.

We are looking forward to your application!

Die Life Science Valley GmbH ist ein Zusammenschluss regionaler Akteure im Göttinger Life-Science-Entrepreneurship-Ökosystem und wurde gemeinsam von Sartorius, der Life Science Factory und der Universitätsmedizin Göttingen initiiert.

Die langfristige Vision dieser Initiative ist es, den Standort Göttingen als einen führenden Life-Science-Hightech-Standort zu positionieren und durch ein schlagkräftiges Inkubator-Konzept eine signifikante Anzahl nachhaltig erfolgreicher Unternehmensgründungen zu befördern. Durch die Bündelung und Ausweitung bestehender Aktivitäten fördert das HTI-Projekt Life Science Valley die Identifikation von Zukunftstechnologien in den Lebenswissenschaften, die unternehmerische Qualifizierung junger Gründungsteams sowie die Bereitstellung einer bedarfsgerechten Infrastruktur.

Zur Unterstützung des Hightech-Inkubator Projektes suchen wir für die neu gegründete Life Science Valley GmbH am Standort Göttingen ab sofort in Vollzeit (40h) oder Teilzeit, zunächst befristet bis Ende 2024, einen Venture Manager [m/w/d].

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